I would drive around the areas you are interested in and get a feel for the neighborhoods. When you find the area that best suits you, based upon your own criteria–close to work, within budget, etc.–check out the zip codes at sdlookup.com, and see what’s available.
As many have mentioned, the construction issues in San Diego vary widely, and if you find something that fits your other criteria, and you get to the point of wanting to make an offer, a good inspection should reveal anything you need to know.
For many of us, it’s all about location, so I definitely would not minimize that element. I know I wouldn’t want to live any place other than where I do, and I think most people on this board feel the same about their respective locations.
The most perfectly constructed home in a location you can’t stand won’t bring much joy to your life, so that’s an important consideration. At least it was for us.
You could also work with one of the excellent realtors who post on this board, if you feel you could use some additional assistance.