I currently have an import/export business working with business in both the U.S. and Asia.
Beyond what Bugs said about working international business, a few more things to keep in mind.
1. Cultural differences between Asians and Americans can be a big deal. We are not talking about stupid social faux pas. We are talking about differences in business ethics, values, approaches and incentives.
2. Work hours. Basically, I work in the day and in the evening. I work Friday nights (since a lot of Asian business work their Sat.) and Sunday nights (Asian’s monday morning). I work during U.S. holidays (because they don’t have the same holiday). I also work during Asian holidays (because business in U.S. doesn’t close on Asian holidays.)