Vees, it is a nice area especially if you have a family.
Excellent weather, not different then anywhere else on the I15 corridor.
Schools are SDUSD and you can check the scores to see how they match up against other areas you want to live in.
Sense of community is better then average for the older homes in the Jerabak area.
Fire hazard of course is high for anywhere along the I15 corridor. Higher for canyon homes.
The commute sucks coming up/down Pomerado but liveable. Spring Canyon is a better way to go.
Mira Mesa Blvd sucks as well but you get used to it. You can take the back way as well, (cristobal)
56 is not a great option. Sometimes miramar can be.
I presume the 92121 option you are thinking of are the homes near Qualcomm Hill on the far west end of Calle Cristobal. Not a bad alternative but I would choose old Scripps for no particular reason.
I don’t think you will go wrong with either selection though with regards to quality of life (the sorrento option is WAY better commute wise) and appreciation wise Scripps may have a slight nod but not a huge difference.