I work in 92121 (incidentally, across the street from one of the offices of a major wireless telecom company) and commute from Rancho Bernardo, it takes me 20 minutes one way.
If you’re willing to deal with an hour of commute, there are many more possibilities, depending on your needs. I actually gave some thought to a house in SW Escondido on two acres of land and 50+ fruit trees – for around 500K.