Everyone is different, but I wouldnt buy anything that was close to Sorrento Valley Blvd/Calle Cristobal. I have been in two differnt houses that border the road, and both have alot of road noise in the back yard. Most of the houses that are for sale in 92121 but-up-against that road. Where else can you drive 50mph legally 20 feet from houses, especially 700k houses?
Most of the people who live in the area work in the Sorrento Valley area, or very near by (carmel valley/La Jolla/pill hill.