[quote=deadzone]If you have to put 20% down then it is not an apples to apples comparison (rent vs. mortgage) in terms of affordability. I would say Mira Mesa is borderline undesirable.[/quote]
Mira Mesa is undesirable to single folks, but very desirable to families. Schools are great and easy to get around. Newer as well, so not as many ghetto houses as North Park, South Park, Clairemont etc.
As mentioned above, use the New York times rent vs. buy calculator. And remember when markets work everyone can spot a bargain. I doubt their are great deals to be had in this market.