At one point, yes, flu, when friends who still live there became so concerned about it–we rallied with them against it–based on “quality of life issues,” as have been discussed.
I have read/heard that over 40K people are expected to move to San Diego this year, with more and more in the future, but, even though projects like One Paseo will help accomodate this need for housing, and may not adversely effect property values, I think it will change the quality of life in “The Valley” (great satire, BTW). Hopefully, most of it will be positive, but only time will tell.