According to my wife, one of the risk is infection. But she say that’s the same risk with a pick line as well. There’s a certain process to prepping the area before accessing the port and if the nurse cut corner, then there would be a risk for infection. She also said the majority of patients who require chemo have the IV Port. As you already know, it just make it easier and not have to get pricked. One complication that you might run into is if it gets clogged. But she said a pick line can also get clocked too. You can get it unclogged though.