Yes, doing business in California sucks, but there are small farming operations that seem to get by.
I don’t know whether adult smokers will grow their own, or buy from a farmer. The vast majority of CA residents live in a climate where the stuff is easily grown, even easier than tomatos, since you don’t have to worry about worms or birds eating the fruit. But, despite living in CA, very few people grow their own veggies; most all buy at the store.
I have a very small vineyard in my back yard, maybe 80 vines. Barely enough to make some home made wine. But, if I replanted the grapes with pot, I would think that would be way more than my family (mom, dad two adult sons) would use.
Maybe I am wrong, but I don’t see any chance for Big Pharma to take over the pot market unless it stays a controlled substance, like a percription drug.