There are lots of wonderful places to live in the world, and it sounds like you just need to find the place or places that bring you a greater sense of fulfillment, scaredy.
Maybe you could keep your present home, and visit or live elsewhere, as your careers permit, in order to test the waters, and then make a full transition later, when you find your dream location.
We find we are drawn to different locations for different reasons, and, although San Diego will always be home base, especially since all of our kids and other family are settled in CA, the experiences of living in various places at different times of the year, has definitely given us a greater sense of fulfillment.