It’s hard to say much without knowing much about your situation. Where will you be working from? Personally, I would really consider the impact of my commute if I were you.
Looks like you are only considering North County? What about Mission Hills, or Kensington, or North Park? Are you willing to go into an older neighborhood?
How important are schools? How many kids and what ages? How important is a yard? Would you trade being able to walk to stores for a smaller house?