It helps you pointed out it’s UCI. UCI takes a more holistic approach with their admission. Unlike UCSD, which is all about the numbers. With UCI, your essay could make a difference – some compelling story why you got a couple Cs on your transcript (got a broken leg and needed rehab for 3 months is not going to cut it). Besides, Bio is still one of the easier majors to get into at UCSD and UCI, no?
Back in my days, UC used the 60/40 ratio for admission. 60% were based strictly on merits, gpa and sat scores. Essays were not even read. Those who didn’t make the cut would have to compete for a spot based on academics, demographics, ethnicity, essays, etc.
BTW, during those years if you finished top 5% (or was it 10%?) at your school you were guaranteed admission.