socratt, there are some cases where people are better off ultimately by building a business opportunity versus blindly investing in markets. The time to do this is in your late 20’s and early 30’s. Good luck on your endeavors.
For others out there … even if you liquidate IRAs (since they have no loan provisions) at least take the loan approach for the last 50k from your 401k.
In many cases you can actually end up with more cash avaliable from the 50% loan than a straight withdrawal due to taxes, phase outs, etc. Do the math.