Mojo – thanks for that link. That was a good explanation:
Alcohol is metabolized principally in the liver, where it is converted first to acetaldehyde by the enzyme alcohol dehydrogenase. Acetaldehyde is then converted to acetate by the enzyme aldehyde dehydrogenase. Acetaldehyde produces unpleasant physiological reactions even at low concentration, so the presence or absence of the gene mutation affecting aldehyde dehydrogenase in turn affects drinking behaviors. When acetaldehyde is not rapidly converted to acetate the results are dramatic: a rapid increase in blood flow to the skin of the face, neck, and chest, rapid heartbeat, headache, nausea, and extreme drowsiness occur. “As expected, this aversive reaction affects drinking behavior,” Li says, “and the mutant gene therefore serves as a protection against heavy drinking and alcoholism. “
I’m sure there are many factors involved in alcohol addiction and/or dependency besides genetics. But that sure doesn’t help matters.
