Ignore the point loma bashers. Until very recently, I lived in an enclave of PL called Sunset Cliffs, which my wife and I consider to be the best neighborhood in the city. If you look on a map of PL, it is west of Catalina and south of Point Loma AVE (not blvd). It is a serene and quiet hillside community overlooking the P. ocean. If you work downtown like I do, you can be at your office in 10-15 minutes. SC is also very safe provided you stay within its bounds.
I agree that other parts of PL are less desirable, but if you are up on the hill you will have a nice view either of downtown (east side of hill), or in the cliffs (west side of hill) you have the ocean.
750-850k buys you less than in other parts of SD (2br, 2000sf was a good buy several months ago), but if location is important to you, there isn’t a better place in the whole city.