If you’re making six figures, you can afford 75% of San Diego and probably 98% of IE, without second income.
What do mean afford? Low 6 figures means low 300’s for purchase price; following the 3X rule. That will certainly get you something (even detached) in Esco, Vista, Oceanside, Ramona and El Cajon/Lakeside/Hell. It still isn’t going to buy anything decent west of the 5 (excluding Oceanside), RB Hillcrest or even dare I say downtown. Sure I could buy a 1 bedroom condo, but if I make 6 figures thats not something decent.