I think the key to survival on 2 wheels is to get as safe as you can and be seen. First, take the course, then do everything else you can. I ride a VStar 1100 (Harley clone) with driving lights, flashing brake lights, crash bars, I wear boots, full helmet and a jacket with spine protection. I never got into the orange vest though.
Not sure how much safer it is with the 3 wheels, but I think dual front brakes and more rubber on the road must mean something. Also, it stands up on its own (might be a bad habit though).