I have to agree with the consensus here. A week ago I left SD at noon on Saturday and it took three and a half hours to get to Hollywood going up the 5 and the 101. It was hellish.
The drive generally isn’t too bad until right around Santa Fe Springs. South of there I-5 has been widened all the way down to the 405 split. But that widening comes to an abrupt halt and you’re down to three, sometimes two lanes. It’s often bad no matter which direction you’re going. Also, being a holiday weekend, it’s likely to be ugly.
405 bunches up around LAX, but the carpool lane helps a lot if you can use it. It also tends to bunch up going up into the valley, but still usually better than the 5. You can also use the toll road and skip a nice chunk of the 405 around South Coast Plaza.
