As you will see from reading the various threads on this board there are as many ideas about the best places to live in San Diego as there are people. In essence, it will come down to your preferences and, of course, your $$$’s.
Just about everyone, including myself, and most of our friends and family, live west of I-5, from Sunset Cliffs and Point Loma to Del Mar and Carlsbad. My family and I live in La Jolla, above LJ Country Club, and overlooking the ocean. It’s beautiful, but be prepared for sticker shock.
We purchased our home almost twenty years ago–when we were in our 20’s–and it’s gone to the moon, but prices are dropping in some areas of LJ, so if you are going to be working in LJ, you might want to check out the zip codes of 92037 and 92038 on realtor.com, to get a feel for the $$$’s and types of homes available. Also check out the Del Mar zip of 92014 and 92130 in Carmel Valley. All of these areas would be highly accessible to a La Jolla commute, and should give you some general price comparisons before you start working with a realtor.