I don’t have the time now to offer up a more detailed response (I have to return to the bench for a timepoint) but what I can briefly say is that San Francisco is NOT a good place to live and work as a member of the rank and file for the Biotech/Pharm sector.
I relocated from there to here for that very reason. The industry as a whole is much stronger in SF compared to San Diego but that doesn’t mean it is any better working there.